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15/09/2025

Cholesterol is Significant Because it is a Vital Substance for Survival

Cholesterol (कोलेस्ट्रॉल) is the principal sterol of all animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Cholesterol is biosynthesized by all animal cells and is an essential structural and signaling component of animal cell membranes. In the brain, astrocytes produce cholesterol and transport it to neurons. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as Mycoplasma, which require cholesterol for growth. It also serves as a precursor for the biosynthesis of steroid hormones, bile acids, and vitamin D. Elevated levels of cholesterol in the blood, especially when bound to low-density lipoprotein (LDL, often referred to as “bad cholesterol”), may increase the risk of cardiovascular disease. François Poulletier de la Salle first identified cholesterol in solid form in gallstones in 1769. 

Cholesterol Meaning

The term “Cholesterol” refers to a waxy, fat-like substance found in all the cells of the body. It is a type of lipid (fat) that is essential for several vital functions, such as building cell membranes and maintaining their structure, producing hormones (like estrogen, testosterone, and cortisol), synthesizing vitamin D, and forming bile acids, which aid in the digestion of fats.

What Your Cholesterol Numbers Really Mean | Lifehacker
Cholesterol is a type of lipid (fat) that is essential for several vital functions, such as building cell membranes and maintaining their structure, producing hormones

Cholesterol Health Risk

It is essential for the body, but too much of the wrong type (mainly LDL and VLDL) can create serious health problems. High cholesterol typically has no symptoms on its own, but it silently increases the risk of several diseases.

Atherosclerosis (Hardening of Arteries)

  • Excess LDL builds up in the artery walls as plaque.

  • This narrows and stiffens arteries, reducing blood flow.

Coronary Artery Disease (Heart Disease)

  • Plaque buildup in the arteries supplying the heart can cause chest pain (angina) or lead to a heart attack.

Stroke

  • If cholesterol plaques block or burst in the brain’s blood vessels, it can cause a stroke.

Peripheral Artery Disease (PAD)

  • Blockages in the arteries of the legs and arms cause pain, numbness, and poor circulation.

High Blood Pressure (Hypertension)

  • Narrowed arteries force the heart to pump harder, raising blood pressure.

Chronic Kidney Disease

  • Plaque buildup can reduce blood supply to the kidneys, impairing their function.

Gallstones

  • Excess cholesterol in bile can form gallstones, resulting in abdominal pain and digestive issues.

Risks of Low Cholesterol (less common)

While high cholesterol is more dangerous, very low can also cause issues such as:

  • Depression and anxiety (cholesterol is needed for brain health).

  • Hormonal imbalances (since it helps make estrogen, testosterone, and cortisol).

  • Increased risk of hemorrhagic stroke (bleeding in the brain).

In short

  • High LDL/VLDL = Clogs arteries → heart attack, stroke, PAD.

  • Low HDL = Less protection → higher risk of heart disease.

  • Very low cholesterol levels can lead to hormonal and brain health issues.

Cholesterol Types

It is carried through the bloodstream by particles called lipoproteins (a combination of fat and protein). Based on the type of lipoprotein, it is divided into several types:

Main Types of Cholesterol

LDL Cholesterol (Low-Density Lipoprotein)

  • Often called “bad cholesterol.”

  • It carries cholesterol to the arteries.

  • If too much LDL builds up, it forms plaque in artery walls (atherosclerosis), increasing the risk of heart attack, stroke, and peripheral artery disease.

HDL Cholesterol (High-Density Lipoprotein)

  • Known as “good cholesterol.”

  • It carries excess cholesterol away from the arteries and back to the liver, where it is broken down and removed from the body.

  • Higher HDL levels lower the risk of heart disease.

VLDL Cholesterol (Very Low-Density Lipoprotein)

  • Another type of “bad” cholesterol.

  • Mainly carries triglycerides (a type of fat) in the blood.

  • High levels can also contribute to plaque buildup in arteries.

Triglycerides (not cholesterol, but often measured together)

  • The most common type of fat in the body.

  • High triglycerides, along with high LDL or low HDL, increase the risk of cardiovascular diseases.

Total Cholesterol

  • The combined measure of LDL + HDL + VLDL (and sometimes triglycerides are factored in).

  • Doctors look at this number along with HDL, LDL, and triglycerides to assess heart health.

Summary

  • LDL = Bad (causes blockages)

  • HDL = Good (cleans arteries)

  • VLDL = Bad (carries triglycerides, causes blockages)

  • Triglycerides = Fat that adds to risk if high

Cholesterol Function

Cholesterol often gets labeled as “bad,” but in reality, it is essential for life. Your body needs cholesterol to perform many important functions. The problem only comes when levels (especially LDL) are too high.

Building Cell Membranes

  • Cholesterol is a structural component of every cell in the body.

  • It helps maintain cell membrane strength, flexibility, and fluidity.

Producing Hormones

  • Cholesterol is the raw material for making vital hormones, including:

    • Sex hormones: Estrogen, progesterone, testosterone.

    • Stress hormones: Cortisol and aldosterone.

Vitamin D Production

  • When skin is exposed to sunlight, cholesterol is used to make vitamin D, which is essential for bones, immunity, and overall health.

Digestive Function (Bile Acid Formation)

  • Cholesterol is used by the liver to produce bile acids.

  • Bile helps digest dietary fats and absorb fat-soluble vitamins (A, D, E, K).

Brain and Nerve Health

  • About 25% of the body’s cholesterol is in the brain.

  • It supports nerve insulation (myelin sheath) and proper signaling between nerve cells.

Wound Healing and Cell Repair

  • Cholesterol is required for making new cells and repairing tissues.

In short, Cholesterol is like a building block and helper molecule—it builds cells, makes hormones and vitamin D, helps digest fats, and keeps the brain and nerves working properly.

Cholesterol Clinical Significance

The significance of cholesterol lies in the fact that it is both essential for life and potentially harmful if imbalanced.

Essential for Life Processes

  • Cholesterol is a building block for cells, hormones, vitamin D, and bile acids.

  • Without it, the body cannot function properly.

Dual Role (Good vs. Bad)

  • HDL (good cholesterol): Protects the heart by removing excess cholesterol.

  • LDL & VLDL (bad cholesterol): Cause artery blockages if in excess.

  • This balance determines whether cholesterol supports health or creates risks.

Indicator of Health

  • Blood cholesterol levels serve as a key indicator of heart disease risk.

  • Doctors use total cholesterol, LDL, HDL, and triglycerides to assess cardiovascular health.

Maintaining Hormonal and Brain Function

  • Cholesterol is vital for hormone production (estrogen, testosterone, cortisol).

  • It supports brain health and nerve signaling, making it crucial for mood, memory, and cognition.

Nutrient Absorption

  • Through bile acid production, cholesterol facilitates the absorption of fat-soluble vitamins (A, D, E, and K), which are essential for immunity, bone health, and vision.

Risk Factor for Diseases

  • High LDL cholesterol is a major risk factor for heart attack, stroke, and peripheral artery disease.

  • Thus, cholesterol levels carry significant predictive value in preventive medicine.

In summary, cholesterol is significant because it is a vital substance for survival, but also a critical health risk factor when out of balance. It represents a “double-edged sword”—necessary in the right amounts, dangerous in excess.

A Table of Positive Significance vs. Negative Significance of Cholesterol

Here’s a clear table of the Positive vs. Negative Significance of Cholesterol

Aspect Positive Significance of Cholesterol Negative Significance of Cholesterol
Cell Health Maintains the structure and fluidity of cell membranes. Excess LDL damages artery walls, forming plaque.
Hormones Needed to produce sex hormones (estrogen, testosterone) and stress hormones (cortisol, aldosterone). Imbalance can disrupt hormone regulation and metabolism.
Vitamin D Essential precursor for Vitamin D synthesis in skin. Deficiency of cholesterol (Hypocholesterolemia) may reduce vitamin D formation.
Digestion Helps form bile acids, which digest fats and absorb vitamins A, D, E, and K. Too much cholesterol in the bile may lead to gallstones.
Brain & Nerves Supports brain function, memory, and nerve insulation (myelin). Excess cholesterol is linked to cognitive decline and stroke.
Energy & Repair Provides raw material for new cells and tissue repair. Excess leads to narrowing of arteries → heart attack, PAD.
Heart & Blood Vessels HDL (“good cholesterol”) removes excess cholesterol, protecting arteries. High LDL/VLDL causes atherosclerosis, hypertension, and cardiovascular disease.

Summary

  • Positive Side → Cholesterol is like the “raw material” for building and maintaining life.

  • Negative Side → If unbalanced, it turns into a “silent killer” by blocking blood vessels.

Cholesterol’s Good and Bad Effects

That’s a very important distinction! Cholesterol plays a dual role — it has both good effects (necessary for health) and bad effects (harmful when imbalanced).

Good Effects of Cholesterol

  1. Cell Structure – Maintains cell membrane strength, flexibility, and protection.

  2. Hormone Production – Essential for making estrogen, testosterone, progesterone, cortisol, and aldosterone.

  3. Vitamin D Synthesis – Helps the body produce vitamin D when skin is exposed to sunlight.

  4. Digestion Support – Forms bile acids, which digest dietary fats and absorb vitamins A, D, E, and K.

  5. Brain & Nerve Health – Supports memory, learning, and nerve insulation (myelin sheath).

  6. Wound Healing & Growth – Provides raw material for new cell and tissue repair.

  7. Protective Role of HDL – “Good cholesterol” removes excess cholesterol from the blood and transports it back to the liver.

Bad Effects of Cholesterol (When in Excess or Imbalanced)

  1. Atherosclerosis – LDL builds up in artery walls, forming plaques that narrow blood vessels.

  2. Heart Disease – Blocked coronary arteries increase the risk of angina and heart attacks.

  3. Stroke – Plaque buildup or rupture in brain arteries may lead to a stroke.

  4. Peripheral Artery Disease (PAD) – Poor blood circulation in legs/arms due to arterial blockages.

  5. High Blood Pressure (Hypertension) – Narrow arteries make the heart pump harder.

  6. Gallstones – Too much cholesterol in the bile may form painful stones.

  7. Cognitive Decline – Excess cholesterol linked to memory problems and dementia risk.

  8. Kidney Damage – Reduced blood flow from cholesterol buildup may impair kidney function.

In Simple Terms

  • Good cholesterol (HDL) = The “cleaner” that removes extra fat from your blood.

  • Bad cholesterol (LDL & VLDL) = The “clogger” that blocks pipes (arteries), causing heart and brain problems.

How to Maintain Healthy Levels of Cholesterol?

Maintaining healthy cholesterol levels is about raising the good (HDL) and lowering the bad (LDL & VLDL). Lifestyle plays the biggest role, though in some cases, medication may also be needed.

Healthy Diet

  • Increase HDL & lower LDL:

    • Eat more fruits, vegetables, whole grains, legumes, and nuts.

    • Use healthy fats like olive oil, sunflower oil, or mustard oil instead of butter/ghee.

    • Eat fatty fish (salmon, mackerel, sardines) rich in omega-3 fatty acids.

  • Reduce LDL & triglycerides:

    • Cut down on red meat, processed meats, fried foods, fast foods, and packaged snacks.

    • Limit trans fats (found in margarine, bakery items, chips).

    • Reduce sugar and refined carbs.

Exercise Regularly

  • Aim for at least 30 minutes of moderate exercise (walking, cycling, swimming, yoga) 5 days a week.

  • Exercise raises HDL (good cholesterol) and lowers LDL & triglycerides.

Maintain a Healthy Weight

  • Losing even 5–10% of body weight can improve cholesterol levels.

  • Prevent belly fat, as it is strongly linked to high LDL and low HDL.

Avoid Smoking & Alcohol

  • Smoking lowers HDL and damages blood vessels. Quitting quickly improves cholesterol.

  • Limit alcohol—moderate intake may raise HDL, but too much increases triglycerides and heart risk.

Manage Stress

  • Chronic stress can raise LDL and triglycerides.

  • Try meditation, pranayama, yoga, deep breathing, or hobbies to reduce stress.

Medical Help (if needed)

  • If lifestyle changes are not enough, doctors may prescribe:

    • Statins (to lower LDL).

    • Fibrates, niacin, or omega-3 supplements (for triglycerides).

    • Cholesterol absorption inhibitors in some cases.

Quick Tips (Remember 5 S’s for Cholesterol Health)

  • Stay Active

  • Skip Junk Foods

  • Switch to Healthy Oils

  • Stop Smoking

  • Stress Less

Plan that Helps Maintain Healthy Cholesterol Levels Naturally

Here’s a daily plan you can follow to naturally maintain healthy cholesterol levels. It combines diet, exercise, and lifestyle habits in a balanced way.

Morning Routine

  • Wake up early (5:30–6:30 AM).

  • Drink warm water with lemon or fenugreek seeds (helps reduce LDL and triglycerides).

  • Exercise 30–40 minutes – brisk walking, jogging, yoga, cycling, or swimming.

    • This raises HDL (good cholesterol).

  • Breakfast (8–9 AM):

    • Oats porridge or whole-grain toast with peanut butter/avocado.

    • A handful of nuts (almonds, walnuts).

    • Fresh fruits (apple, orange, or papaya).

    • Green tea instead of coffee with sugar.

Mid-Morning Snack (11 AM)

  • Seasonal fruit (guava, berries, pear).

  • 1 glass of buttermilk or green smoothie with spinach + cucumber + mint.

Lunch (1–2 PM)

  • Whole grains: Brown rice, quinoa, or millet roti.

  • Protein: Lentils (dal), beans, chickpeas, or grilled fish/chicken (in moderation).

  • Vegetables: At least half the plate with colorful veggies.

  • Healthy fats: Add olive oil, flaxseeds, or sesame seeds to salad.

Evening Snack (4–5 PM)

  • Handful of roasted chana (chickpeas) or sprouts salad.

  • Herbal tea / green tea/lemon water.

Dinner (7–8 PM)

  • Light and easy to digest.

  • Vegetable soup + multigrain chapati, or grilled vegetables with dal.

  • Small portion of lean protein (fish, paneer, tofu).

  • Avoid heavy, fried, or late-night meals.

Before Bed (9–10 PM)

  • Warm turmeric milk (low-fat).

  • Deep breathing or meditation for 10–15 minutes to reduce stress.

  • Sleep early (7–8 hrs of quality sleep).

Lifestyle Guidelines

  • Avoid: Junk food, processed meat, fried snacks, excess sweets, and trans fats.

  • Include: High-fiber foods (oats, flaxseeds, whole grains, vegetables).

  • Stay active: Walk after meals for 10–15 minutes.

  • Stay hydrated: Drink 2.5–3 liters of water daily.

  • Quit smoking & limit alcohol.

In summary, this plan helps lower bad cholesterol (LDL & triglycerides) and increase good cholesterol (HDL) naturally through balanced food choices, exercise, stress control, and proper sleep.

Conclusion

Cholesterol is a vital substance in the human body, serving as a building block for cell membranes, hormones, vitamin D, and bile acids that aid digestion. While it is essential for life, an imbalance in levels—particularly high LDL and low HDL—can silently increase the risk of heart disease, stroke, and other health complications. Thus, it represents both a friend and a foe: beneficial when maintained in healthy ranges, but harmful when neglected. By adopting a balanced diet, staying physically active, managing stress, avoiding smoking, and seeking medical care when necessary, one can maintain optimal levels and protect long-term heart and overall health.

Frequently Asked Questions

1. What is cholesterol?

It is a waxy, fat-like substance found in the body’s cells. It helps build cell membranes, produce hormones, vitamin D, and bile acids.


2. Why is cholesterol important?

It is essential for cell structure, hormone production, brain function, digestion, and vitamin D synthesis. Without it, the body cannot function properly.


3. What are the types of cholesterol?

  • LDL (Low-Density Lipoprotein): “Bad” that can clog arteries.

  • HDL (High-Density Lipoprotein): “Good” that removes excess cholesterol.

  • VLDL (Very Low-Density Lipoprotein): Carries triglycerides and can also block arteries.


4. What are healthy cholesterol levels?

  • Total: Less than 200 mg/dL

  • LDL: Less than 100 mg/dL

  • HDL: 40 mg/dL or higher (men), 50 mg/dL or higher (women)

  • Triglycerides: Less than 150 mg/dL


5. What happens if cholesterol levels are too high?

High levels can cause plaque buildup in arteries, leading to atherosclerosis, heart disease, stroke, peripheral artery disease, and high blood pressure.


6. Can low cholesterol be harmful?

Yes. Very low levels can affect hormone production, brain function, and may increase the risk of depression, anxiety, and hemorrhagic stroke.


7. How can I check my cholesterol levels?

A simple blood test called a lipid profile measures total cholesterol, LDL, HDL, and triglycerides.


8. How can I naturally maintain healthy cholesterol?

Eat a heart-healthy diet, exercise regularly, maintain a healthy weight, quit smoking, reduce stress, and limit alcohol.


9. Do I need medicines to control cholesterol?

Not always. Lifestyle changes are usually enough, but if levels remain high, doctors may prescribe statins or other medications.


10. What foods should I avoid to reduce bad cholesterol?

Limit fried foods, processed meats, packaged snacks, full-fat dairy, fast food, and foods with trans fats or excess sugar.

Reference: https://en.wikipedia.org/wiki/Cholesterol

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