Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney. These cysts may begin to develop in utero, infancy, childhood, or in adulthood. Cysts are non-functioning tubules filled with fluid pumped into them, which range in size from microscopic to enormous, crushing adjacent normal tubules and eventually rendering them non-functional as well. The genetic defect can also cause aortic root aneurysms, and aneurysms in the circle of Willis cerebral arteries, which if they rupture, can cause a subarachnoid hemorrhage.
Polycystic kidney disease Meaning
Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid. The cysts vary in size, and they can grow very large.
Polycystic kidney disease Complications
Complications include hypertension due to the activation of the renin-angiotensin-aldosterone system (RAAS), frequent cyst infections, urinary bleeding, and declining renal function. Hypertension is treated with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs). Declining renal function is treated with renal replacement therapy (RRT): dialysis and/or transplantation. Management from the time of the suspected or definitive diagnosis is by a board-certified nephrologist.
Who is more likely to have PKD?
PKD affects people of all ages, races, and ethnicities worldwide. The disorder occurs equally in women and men.
Polycystic kidney disease Risk factors
The most common risk factor of PKD is positive family history. Family history is a cheap and easy way to approach the diagnosis of ADPKD.
Polycystic kidney disease Symptoms
Signs and symptoms include high blood pressure, headaches, abdominal pain, blood in the urine, and excessive urination. Other symptoms include pain in the back, and cyst formation (renal and other organs).
Polycystic kidney disease Cause
PKD is a general term for two types, each having its own pathology and genetic cause: autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD).
Autosomal dominant
Autosomal dominant polycystic kidney disease (ADPKD) is the most common of all inherited cystic kidney diseases with an incidence of 1:500 live births. Studies show that 10% of end-stage kidney disease (ESKD) patients being treated with dialysis in Europe and the U.S. were initially diagnosed and treated for ADPKD.
Genetic mutations
Genetic mutations in any of the three genes PKD1, PKD2, and PKD3 have similar phenotypical presentations.
- Gene PKD1 is located on chromosome 16 and codes for a protein involved in the regulation of the cell cycle and intracellular calcium transport in epithelial cells and is responsible for 85% of the cases of ADPKD.
- A group of voltage-linked cation channels, with inward selectivity for K>Na>>Ca and outward selectivity are coded for by PKD2 on chromosome 4
- PKD3 recently appeared in research papers as a postulated third gene. Fewer than 10% of cases of ADPKD appear in non-ADPKD families. Cyst formation begins in utero from any point along the nephron, although fewer than 5% of nephrons are thought to be involved. As the cysts accumulate fluid, they enlarge, separate entirely from the nephron, compress the neighboring kidney parenchyma, and progressively compromise kidney function.
Polycystic kidney disease Autosomal recessive
Autosomal recessive polycystic kidney disease (ARPKD) (OMIM #263200) is the less common of the two types of PKD, with an incidence of 1:20,000 live births, and is typically identified in the first few weeks after birth. Unfortunately, the kidneys are often underdeveloped resulting in a 30% death rate in newborns with ARPKD. PKHD1 is involved.
Polycystic kidney disease Mechanism
Polycystin-1 and polycystin-2 proteins
Both autosomal dominant and autosomal recessive polycystic kidney disease cyst formation is tied to abnormal cilia-mediated signaling. The polycystin-1 and polycystin-2 proteins appear to be involved in both autosomal dominant and recessive polycystic kidney disease due to defects in both proteins.
Both proteins communicate with calcium channel proteins and cause a reduction in resting (intracellular) calcium and endoplasmic reticulum storage of calcium.
Defects in the primary cilium
PKD results from defects in the primary cilium, an immotile, hair-like cellular organelle present on the surface of most cells in the body, anchored in the cell body by the basal body. In the kidney, primary cilia have been found to be present on most cells of the nephron, projecting from the apical surface of the renal epithelium into the tubule lumen.
Polycystic kidney disease Diagnosis
Polycystic kidney disease can be ascertained via a CT scan of the abdomen, as well as, an MRI and ultrasound of the same area. A physical exam/test can reveal enlarged liver, heart murmurs, and elevated blood pressure.
Can I prevent PKD?
Researchers have not yet found a way to prevent PKD. However, you may be able to slow PKD problems caused by high blood pressure, such as kidney damage. Aim for a blood pressure goal of less than 120/80. Work with a healthcare team to help manage your or your child’s PKD. The health care team will probably include a general practitioner and a nephrologist, a health care provider specializing in kidney health.
Polycystic kidney disease Treatment
No FDA-approved treatment
There is no FDA-approved treatment. However, recent research indicates that mild to moderate dietary restrictions slow the progression of autosomal dominant polycystic kidney disease (ADPKD) in mice.
If and when the disease progresses enough in a given case, the nephrologist or other practitioner and the patient will have to decide what form of renal replacement therapy will be used to treat end-stage kidney disease (kidney failure, typically stage 4 or 5 of chronic kidney disease).
Dialysis
That will either be some form of dialysis, which can be done at least two different ways at varying frequencies and durations (whether it is done at home or in the clinic depends on the method used and the patient’s stability and training) and eventually, if they are eligible because of the nature and severity of their condition and if a suitable match can be found, unilateral or bilateral kidney transplantation.
Bacteriostatic and bacteriocidal drugs
A Cochrane Review study of autosomal dominant polycystic kidney disease made note of the fact that it is important at all times, while avoiding antibiotic resistance, to control infections of the cysts in the kidneys, and if affected, the liver, when needed for a certain duration to combat infection, by using, “bacteriostatic and bacteriocidal drugs”.
Polycystic kidney disease Prognosis
ADPKD individuals might have a normal life; conversely, ARPKD can cause kidney dysfunction and can lead to kidney failure by the age of 40–60. ADPKD1 and ADPKD2 are very different, in that ADPKD2 are much milder.
Polycystic kidney disease Epidemiology
PKD is one of the most common hereditary diseases in the United States, affecting more than 600,000 people. It is the cause of nearly 10% of all end-stage renal diseases. It equally affects men, women, and all races. PKD occurs in some animals as well as humans.
Ayurveda for Polycystic kidney disease
Polycystic kidney disease treatment in Ayurvedic is the safest and pure way for curing kidneys. It works by changing the diet and lifestyle. Ayurveda basically plays a very important role in our health and life. You must have heard from your grandparents about the healing powers of herbs.
Ayurveda takes a lot of determination and control to show the results. If one really wants to cure a problem, one needs to follow the proper diet and important instructions. Ayurveda Treatment includes Herbal medicines to keep all organs free from infections and other complications caused by PKD.
Nowadays, people all around the globe are focusing on maintaining a healthy BODY and mind. So, choosing Polycystic Kidney Disease Treatment in Ayurvedic is a good decision.
Controls the blood pressure
High blood pressure is a common reason for kidney disease whether it is Polycystic kidney disease or chronic kidney disease. Patients with PKD need to control their high blood pressure anyhow.
Some tips to control high BP
* The right diet also helps to control high blood pressure. Patients can consult with their doctor that what type of food they can add to their diet to control high blood pressure.
* Try to lose extra weight because it increases the heartbeat after doing any physical activity and that may cause high blood flow in the body. High blood flow can cause high blood pressure.
* Take a less salt diet.
* Expressing gratitude to others helps to be happier and also reduces stress.
* Drink ginger tea or green tea instead of caffeine to reduce stress and keep the body.
* Keep your mind calm by doing things that make you happy.
* Do regular meditation to reduce stress.
* Regular yoga and breathing exercise to keep your body healthy.
* Don’t take too many medicines to reduce high blood pressure.
Work to reduce the growth of cysts
Take medicines that help to reduce the development of cysts on the surface of the kidneys. In allopathic treatment, doctors remove the fluid from the cysts with the help of needles. This method is so painful and risky for patients. If we talk about Ayurveda, it works on the roots. This is the reason Ayurveda is best for polycystic kidney disease.
Sufficient water intake
The body needs a sufficient level of water to work its function properly. Too much fluid or less fluid both are unhealthy for the body and causes many health-related complications. that’s the reason doctors suggest they take a sufficient amount of water according to the body’s needs.
Herbal syrups and powders to reduce pain
As in polycystic kidney disease growth of cysts develops on the surface of the kidney that causes severe pain in the sides of the belly and in the stomach. Polycystic Kidney Disease Treatment in Ayurveda includes herbal syrups and powders that are made from pure herbs to reduce pain.
Avoid consumption of alcohol, oily food, and junk food
Make sure if someone has a bad habit of consuming alcohol then they need to quit it anyhow.
Changes in lifestyle and diet
An unhealthy diet and improper lifestyle are becoming the cause of kidney disease whether it is chronic kidney disease or polycystic kidney disease. This is for everyone to change or can say improve their lifestyle and eating habits. A healthy diet and proper lifestyle help to overcome related causes and other complications and risks of the disease.
Don’t depend on antibiotics and painkillers
Painkillers help to give us instant relief but what about organ loss in the future? Excess of everything is morbid. One can replace antibiotics and painkillers with healthy alternative methods.
Consume fresh vegetables and fruits
A healthy diet is a combination of fruit, vegetables, and whole grain. Consuming these can be helpful to keep the body healthy.
Stay hydrated
Drink a sufficient amount of water that a body needs but make sure don’t drink too much water.
Do not smoke
Avoid smoking because too much smoking causes diseases such as heart disease, liver disease, and kidney disease.
Siddha remedies for Polycystic kidney disease
1. Siddha preventive measures
Everybody must practice Siddha preventive measures, whether a person is affected by Polycystic Kidney Disease or not, but preventive measures are the primary steps for switching on to any other Siddha remedies, and hence they are important. It helps in one’s capability, effectiveness, productivity, decision-making power, intellectuality, and removing minor health problems. There are three types of preventive measures:
- Earthing – performed for removing and earthing the negativity of our body
- Field cleaning – cleans the energy field (Aura) of our body
- Siddha brain exercise/Energizing – energizes our brain for proper functionality
Everybody’s tendency is to get attracted to the word ‘free, however, don’t neglect even these Siddha preventive measures are free. Avail of the benefits by practicing them sincerely, and regularly. For ease of understanding of what Siddha preventive measures are, please watch a video for a live demonstration.
2. Siddha Shaktidata Yoga
This unique Siddha Shaktidata Yoga of Siddha Spirituality can solve the problems related to Polycystic Kidney Disease. There is no compulsion of training in ‘Swami Hardas Life System’ methods. This not only gives benefits to self but also it can be used for other affected persons, whether a person is in the same house, distantly available in the same city, same nation, or might be in any corner of the world, however, both the procedures have been explained here.
3. Siddha Kalyan Sadhana
Recite this Sadhana with a Sankalp “My problems of Polycystic Kidney Disease are solved as early as possible and I should gain health”, which should be repeated in mind 3 – 3 times after each stanza. Any person irrespective of caste, creed, religion, faith, sex, and age can recite this Sadhana for free, which should be repeated at least twice a day. To know more, please click on this link.
4. CCPE products for Polycystic kidney disease
These products work on the concepts of ‘Conceptual CreativePositive Energy’ (CCPE) within the provisions of the ‘CCPE Life System’ and the theory of Quantum Technology to a certain extent. However, please use these products for Polycystic Kidney Disease as mentioned below:
CCPE Extractor: The CCPE Extractor should be gently moved over the Agya Chakra in a circular motion at least for 30 to 60 seconds, thereafter, follow the same process on the head, and both kidneys which finish within almost 2-4 minutes.
CCPE Booster: Keep one Booster over the Agya Chakra and another on the head, and both kidneys for 3 minutes. You may need to have 2 Boosters, which establishes positivity.
5. UAM or Touch Therapy for Polycystic kidney disease
For quick and effective results, it is advisable to learn the unique methods of the Swami Hardas Life System. A trained person can only apply the UAM method or Touch therapy himself/herself and also become capable of healing others.
In general, a daily routine for Polycystic Kidney Disease may look like this:
- Follow the instructions of your Doctor
- Consume Sattvic diet
- Perform breathing exercises regularly
- Perform walking exercises
- Apply free touch therapy (UAM) a minimum 3 times a day, as explained above
- Perform Swayamsiddha Agnihotra or Agnihotra daily, either self or the caretaker can perform
- In case, if someone wishes to learn advanced methods of Swami Hardas Life System, undergo unique training
Ensure to sprinkle in some fun during the day: Don’t forget to relax and laugh in between. Laughing is a great way to boost your immune system and help you.
Along with all the above activities, apply above explained free Siddha remedies minimum 3 times a day, the more is good. Just try the methods of Siddha Spirituality of Swami Hardas Life System. I am confident that you will surely find improvements within 3 days.
Training of Swami Hardas Life System
Any health, peace, and the progress-related problem can be solved independently by undergoing Swami Hardas Life System training. It needs no money or medicines. Any person irrespective of religion, caste, creed, faith, sex, and age can undergo this unique training.
Conclusion
Because of the above, I am confident that you have learned about Polycystic Kidney Disease, its meaning, symptoms, causes, diagnosis, treatment, prevention, Ayurveda treatments, and Siddha remedies. Now, that you have become self-sufficient, hence it’s the right time to use your acquired knowledge for solving problems as per the provision available in Siddha Spirituality of Swami Hardas Life System.
However, keep learning and practicing the free Siddha remedies, which would help guide how to solve various problems regarding health, peace, and progress, without money and medicines.
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Frequently asked questions
Before posting your query, kindly go through the:
| What is PKD?
Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid. The cysts vary in size, and they can grow very large. |
| What are the symptoms of PKD?
Signs and symptoms include high blood pressure, headaches, abdominal pain, blood in the urine, and excessive urination. Other symptoms include pain in the back, and cyst formation (renal and other organs). |
| Is Polycystic Kidney Disease preventable?
Researchers have not yet found a way to prevent PKD. However, you may be able to slow PKD problems caused by high blood pressure, such as kidney damage. Aim for a blood pressure goal of less than 120/80. Work with a healthcare team to help manage your or your child’s PKD. The health care team will probably include a general practitioner and a nephrologist, a health care provider specializing in kidney health. |
Reference: https://en.wikipedia.org/wiki/Polycystic_kidney_disease