Myasthenia Gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. Onset can be sudden. Those affected often have a large thymus or develop a thymoma. MG is generally treated with medications known as acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine. MG affects 50 to 200 per million people. It is newly diagnosed in three to 30 per million people each year. Let us find out if Siddha remedies of Swami Hardas Life System can be helpful in correcting MG.
What is Myasthenia Gravis?
Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. With current therapies, however, most cases of myasthenia gravis are not as “grave” as the name implies. In fact, most individuals with myasthenia gravis have a normal life expectancy.
Myasthenia Gravis Risk Factors
A 2018 Swedish study found that those with the late-onset disease had a more disadvantageous pattern of lifestyle-related risk factors and a higher rate of:
- Smoking,
- Obesity,
- Physical inactivity, and
- Insufficient diet (including a lower rate of fish consumption).
General Risk factors
General risk factors found to increase the chance of a person getting MG to include:
- Being a woman between the ages of 20 to 30,
- Being a man between the ages of 60 to 70, and
- Neonates (newborn infants) with mothers who have abnormal antibodies that have entered the baby’s body via the placenta during pregnancy.
Myasthenia Gravis Types
Congenital myasthenia gravis
Congenital MG is estimated to occur in 2–12 people per million and is typically inherited instead of being caused by a malfunction of the body’s immune system.
There are several types of congenital MG, depending on the type of genetic defect a patient harbors and at which point of the nerve-muscle communication signaling cascade there are impairments.
Ocular myasthenia gravis
In 10–40% of MG patients, symptoms of muscle weakness and fatigue are restricted to the muscles that control eye and eyelid movements. Patients with this type of MG, called ocular MG, tend to experience eyelid droopiness and double vision as their eyes and eyelid muscles progressively lose strength.
While many patients with other forms of MG first experience symptoms in these muscles before the disease progresses and spreads to other muscle groups, in those with ocular MG, symptoms of muscle weakness and fatigue do not spread to other muscles in the body.
Generalized myasthenia gravis
About 50–80% of patients with eye symptoms develop generalized MG. This specific type of the disease is characterized by widespread muscle weakness and fatigue that is not confined to eye and eyelid muscles, or any other specific muscle groups. It may spread to muscles in the face, as well as those in the limbs.
In approximately 10% of these patients, muscle weakness spreads to respiratory muscles or those of the throat and jaw. This can make breathing fairly difficult and lead to potentially life-threatening episodes known as myasthenic crises.
Generalized MG is more common in women than in men, particularly in those younger than 40.
Transient neonatal myasthenia gravis
This type of MG is reported to be rare and thought to occur in 10–20% of infants born to mothers with the disease.
During pregnancy, the mother’s self-reactive antibodies can be passed on to the unborn child, resulting in the destruction of acetylcholine receptors in the fetus.
Newborns typically develop symptoms of transient neonatal MG shortly after birth. Symptoms may include overall muscle weakness, impaired sucking and swallowing, a weak cry, and respiratory insufficiency. While serious, these symptoms usually disappear within a few days or weeks.
Juvenile myasthenia gravis
In juvenile MG, symptoms begin before the onset of puberty. In its most benign form, juvenile MG is confined to eye muscles, but severe cases involving other muscle groups have been reported. Symptoms can range from clumsiness to swallowing difficulties to tiring easily.
Many of these patients have an abnormal growth of the thymus — a gland that is part of the immune system and thought to trigger or help maintain the production of the harmful self-reactive antibodies that impair nerve-muscle communication in MG. As such, a possible treatment is surgically removing this gland, a procedure called thymectomy.
Myasthenia Gravis Symptoms
The initial, main symptom in MG is a painless weakness of specific muscles, not fatigue. The muscle weakness becomes progressively worse during periods of physical activity and improves after periods of rest. Typically, the weakness and fatigue are worse toward the end of the day. MG generally starts with ocular (eye) weakness; it might then progress to a more severe generalized form, characterized by weakness in the extremities or in muscles that govern basic life functions.
Eyes
In about two-thirds of individuals, the initial symptom of MG is related to the muscles around the eye. Eyelid drooping (ptosis may occur due to weakness of m. levator palpebrae superioris) and double vision (diplopia, due to weakness of the extraocular muscles).
Eye symptoms tend to get worse when watching television, reading, or driving, particularly in bright conditions. Consequently, some affected individuals choose to wear sunglasses. The term “ocular myasthenia gravis” describes a subtype of MG where muscle weakness is confined to the eyes, i.e. extraocular muscles, m. levator palpebrae superioris, and m. orbicularis oculi. Typically, this subtype evolves into generalized MG, usually after a few years.
Eating
The weakness of the muscles involved in swallowing may lead to swallowing difficulty (dysphagia). Typically, this means that some food may be left in the mouth after an attempt to swallow, or food and liquids may regurgitate into the nose rather than go down the throat (velopharyngeal insufficiency). Weakness of the muscles that move the jaw (muscles of mastication) may cause difficulty chewing. In individuals with MG, chewing tends to become more tiring when chewing tough, fibrous foods. Difficulty in swallowing, chewing, and speaking is the first symptom in about one-sixth of individuals.
Speaking
Weakness of the muscles involved in speaking may lead to dysarthria and hypophonia. Speech may be slow and slurred or have a nasal quality. In some cases, a singing hobby or profession must be abandoned.
Head and neck
Due to weakness of the muscles of facial expression and muscles of mastication, facial weakness may manifest as the inability to hold the mouth closed (the “hanging jaw sign”) and as a snarling expression when attempting to smile. With drooping eyelids, facial weakness may make the individual appear sleepy or sad. Difficulty in holding the head upright may occur.
Other
The muscles that control breathing and limb movements can also be affected; rarely do these present as the first symptoms of MG, but develop over months to years. In a myasthenic crisis, a paralysis of the respiratory muscles occurs, necessitating assisted ventilation to sustain life. Crises may be triggered by various biological stressors such as infection, fever, an adverse reaction to a medication, or emotional stress.
Myasthenia Gravis Pathophysiology
Autoimmune synaptopathy
MG is an autoimmune synaptopathy. The disorder occurs when the immune system malfunctions and generates antibodies that attack the body’s tissues. The antibodies in MG attack a normal human protein, the nicotinic acetylcholine receptor, or a related protein called MuSK, a muscle-specific kinase. Other, less frequent antibodies are found against LRP4, agrin, and titin proteins.
Human leukocyte antigen haplotypes
Human leukocyte antigen haplotypes are associated with increased susceptibility to myasthenia gravis and other autoimmune disorders. Relatives of people with MG have a higher percentage of other immune disorders.
Thymus gland cells
The thymus gland cells form part of the body’s immune system. In those with myasthenia gravis, the thymus gland is large and abnormal. It sometimes contains clusters of immune cells that indicate lymphoid hyperplasia, and the thymus gland may give wrong instructions to immune cells.
Myasthenia Gravis in pregnancy
For women who are pregnant and already have MG, in a third of cases, they have been known to experience an exacerbation of their symptoms, and in those cases, it usually occurs in the first trimester of pregnancy.
Signs and symptoms in pregnant mothers tend to improve during the second and third trimesters. Complete remission can occur in some mothers. Immunosuppressive therapy should be maintained throughout pregnancy, as this reduces the chance of neonatal muscle weakness, and controls the mother’s myasthenia.
Myasthenia Gravis Diagnosis
MG can be difficult to diagnose, as the symptoms can be subtle and hard to distinguish from both normal variants and other neurological disorders.
Three types of myasthenic symptoms in children can be distinguished:
- Transient neonatal myasthenia occurs in 10 to 15% of babies born to mothers afflicted with the disorder and disappears after a few weeks.
- Congenital myasthenia, the rarest form, occurs when genes are present in both parents.
- Juvenile myasthenia gravis is most common in females.
Congenital myasthenias cause muscle weakness and fatigability similar to those of MG. The signs of congenital myasthenia usually are present in the first years of childhood, although they may not be recognized until adulthood.
Physical examination of Myasthenia Gravis
During a physical examination to check for MG, a doctor might ask the person to perform repetitive movements. For instance, the doctor may ask one to look at a fixed point for 30 seconds and to relax the muscles of the forehead, because a person with MG and ptosis of the eyes might be involuntarily using the forehead muscles to compensate for the weakness in the eyelids.
The clinical examiner might also try to elicit the “curtain sign” in a person by holding one of the person’s eyes open, which in the case of MG will lead the other eye to close.
Blood tests
If the diagnosis is suspected, serology can be performed:
- One test is for antibodies against the acetylcholine receptor; the test has a reasonable sensitivity of 80–96%, but in ocular myasthenia, the sensitivity falls to 50%.
- A proportion of the people without antibodies against the acetylcholine receptor have antibodies against the MuSK protein.
- In specific situations, testing is performed for Lambert-Eaton syndrome.
Electrodiagnostics
In single-fiber electromyography, which is considered to be the most sensitive test for MG, a thin needle electrode is inserted into different areas of a particular muscle to record the action potentials from several samplings of different individual muscle fibers.
Ice test
Applying ice for 2–5 minutes to the muscles reportedly has a sensitivity and specificity of 76.9% and 98.3%, respectively, for the identification of MG.
Edrophonium test
This test requires the intravenous administration of edrophonium chloride or neostigmine, drugs that block the breakdown of acetylcholine by cholinesterase (acetylcholinesterase inhibitors).
This test is no longer typically performed, as its use can lead to life-threatening bradycardia (slow heart rate) which requires immediate emergency attention. Production of edrophonium was discontinued in 2008.
Imaging
A chest X-ray may identify widening of the mediastinum suggestive of thymoma, but computed tomography or magnetic resonance imaging (MRI) are more sensitive ways to identify thymomas and are generally done for this reason.
Myasthenia Gravis Prevention
Many lifestyle changes may help prevent flare-ups and lower the chances of worsening symptoms, these lifestyle changes include:
- Getting plenty of sleep,
- Taking rest periods when needed,
- Avoiding strenuous or exhausting activities,
- Staying out of the extreme heat and cold,
- Coping with emotional stressors,
- Avoiding infections when possible, and
- Working with your healthcare provider to avoid drugs that worsen MG.
Myasthenia Gravis Treatment
Treatment is by medication and/or surgery. Medication consists mainly of acetylcholinesterase inhibitors to directly improve muscle function and immunosuppressant drugs to reduce the autoimmune process. Thymectomy is a surgical method to treat MG.
Medication
Worsening may occur with medication such as fluoroquinolones, aminoglycosides, and magnesium. About 10% of people with generalized MG are considered treatment-refractory.
Acetylcholinesterase inhibitors
Acetylcholinesterase inhibitors can provide symptomatic benefits and may not fully remove a person’s weakness from MG. While they might not fully remove all symptoms of MG, they still may allow a person the ability to perform normal daily activities.
If taken 30 minutes before a meal, symptoms will be mild during eating, which is helpful for those who have difficulty swallowing due to their illness.
Immune suppressants
The steroid prednisone might also be used to achieve a better result, but it can lead to the worsening of symptoms for 14 days and takes 6–8 weeks to achieve its maximal effectiveness.
Due to the myriad symptoms that steroid treatments can cause, it is not the preferred method of treatment. Other immune-suppressing medications may also be used including rituximab.
Plasmapheresis and IVIG
If the myasthenia is serious (myasthenic crisis), plasmapheresis can be used to remove the putative antibodies from the circulation. Also, intravenous immunoglobulins (IVIGs) can be used to bind the circulating antibodies.
Surgery
As thymomas are seen in 10% of all people with the MG, they are often given a chest X-ray and CT scan to evaluate their need for surgical removal of their thymus glands and any cancerous tissue that may be present.
A 2016 randomized, controlled trial, however, found some benefits.
Physical measures
In people with generalized MG, some evidence indicates a partial home program including training in diaphragmatic breathing, pursed-lip breathing, and interval-based muscle therapy may improve respiratory muscle strength, chest wall mobility, respiratory pattern, and respiratory endurance.
Medical imaging
In people with myasthenia gravis, older forms of iodinated contrast used for medical imaging have caused an increased risk of exacerbation of the disease, but modern forms have no immediate increased risk.
Myasthenia Gravis Prognosis
The prognosis of people with MG is generally good, as is the quality of life, given very good treatment. Monitoring a person with MG is very important, as at least 20% of people diagnosed with it will experience a myasthenic crisis within two years of their diagnosis, requiring rapid medical intervention.
Generally, the most disabling period of MG might be years after the initial diagnosis. In the early 1900s, 70% of detected cases died from lung problems.
Ayurveda treatment for Myasthenia Gravis
The doctors carry out physical exams and check the medical history of the patient. There is also a series of neurological exams that include checking reflexes, weakness in muscles, checking muscle toning, ensuring proper eye movement, and several other tests.
Ayurveda explains Myasthenia Gravis as the vitiation of Vata and Kapha dosha at the site of muscles. The specific dosha vitiation leads to several complications.
Ayurvedic treatment for Myasthenia Gravis provides adequate relief in all the symptoms, improves daily lifestyle quality, and improves muscle growth and health.
Panchakarma therapies
It suggests Panchakarma therapies such as Abhyanga, Nasya, Kizi Sweden, Shalishashtik Sweden, and Vasti. These therapies help improve nerve-muscle coordination by removing toxins from the body. It is an effective and proven natural treatment for myasthenia gravis. Its therapies and medication treat the disease in a natural way and help the patient recover without any side effects.
The Panchakarma therapies used in the process are helpful in relieving the symptoms and myasthenia gravis management.
Exercises for Myasthenia Gravis
There are a number of exercises that may help in improving the symptoms of myasthenia gravis. Breathing exercises and Pranayam can really help in improving the overall wellness of the patient and thus improve the disease symptoms.
Siddha remedies for Myasthenia Gravis
1. Siddha preventive measures
Everybody must practice Siddha preventive measures, whether a person is affected by myasthenia gravis or not, but preventive measures are the primary steps for switching on to any other Siddha remedies, and hence they are important. It helps in one’s capability, effectiveness, productivity, decision-making power, intellectuality, and removing minor health problems. There are three types of preventive measures:
- Earthing – performed for removing and earthing the negativity of our body
- Field cleaning – cleans the energy field (Aura) of our body
- Siddha brain exercise/Energizing – energizes our brain for proper functionality
Everybody’s tendency is to get attracted to the word ‘free, however, don’t neglect even these Siddha preventive measures are free. Avail of the benefits by practicing them sincerely, and regularly. For ease of understanding what Siddha preventive measures are, please watch a video for a live demonstration.
2. Siddha Shaktidata Yoga
This unique Siddha Shaktidata Yoga of Siddha Spirituality can solve the problems related to myasthenia gravis with Siddha remedies. There is no compulsion of training in ‘Swami Hardas Life System’ methods. This not only gives benefits to self but also it can be used for other affected persons, whether a person is in the same house, distantly available in the same city, same nation, or might be in any corner of the world, however, both the procedures have been explained here.
3. Siddha Kalyan Sadhana
Recite this Sadhana with a Sankalp “My problems of myasthenia gravis are solved as early as possible and I should gain health”, which should be repeated in mind 3 – 3 times after each stanza. Any person irrespective of caste, creed, religion, faith, sex, and age can recite this Sadhana for free, which should be repeated at least twice a day. To know more, please click on this link.
4. CCPE products for Myasthenia gravis
These products work on the concepts of ‘Conceptual Creative Positive Energy’ (CCPE) within the provisions of the ‘CCPE Life System’ and the theory of Quantum Technology to a certain extent. However, please use these products for uterine cancer as mentioned below:
CCPE Extractor: The CCPE Extractor should be gently moved over the Agya Chakra in a circular motion at least for 30 to 60 seconds, thereafter, follow the same process on the affected part which finishes within almost 1-2 minutes.
CCPE Booster: Keep one Booster over the Agya Chakra and another over the affected part for 3 minutes. You may need to have 2 Boosters, which establishes positivity.
CCPE Booster Powder: Mix a pinch of CCPE booster powder with a few drops of coconut oil and make a paste. Apply it over the affected part, and leave it for about 30 minutes. Repeat the process every after 2 hours.
5. UAM or Touch Therapy for Myasthenia gravis
For quick and effective results, it is advisable to learn the unique methods of the Swami Hardas Life System. A trained person can only apply the UAM method or Touch therapy himself/herself and become capable of healing others.
A daily routine for Myasthenia gravis
In general, a daily routine for myasthenia gravis may look like this:
- Follow the instructions of your Doctor
- Consume Sattvic diet
- Get rid of obesity, if you are obese or overweight
- Perform breathing exercises regularly
- Apply free touch therapy (UAM) a minimum 3 times a day, as explained above
- Perform Swayamsiddha Agnihotra daily, either self or the caretaker can perform
- In case, if someone wishes to learn advanced methods of Swami Hardas Life System, undergo unique training
Ensure to sprinkle in some fun during the day: Don’t forget to relax and laugh in between. Laughing is a great way to boost your immune system and help you.
Along with all the above activities, apply above explained free Siddha remedies minimum 3 times a day, the more is good. Just try the methods of Siddha Spirituality of Swami Hardas Life System. I am confident that you will surely find improvements within 3 days.
Training of Swami Hardas Life System
Any health, peace, and progress-related problem can be solved independently by undergoing Swami Hardas Life System training. It needs no money and medicines. Any person irrespective of religion, caste, creed, faith, sex, and age can undergo this unique training.
Conclusion
Because of the above, I am confident that you have learned about myasthenia gravis, its meaning, types, symptoms, risk factors, causes, diagnosis, prevention, treatment, Ayurveda treatment, exercises, and Siddha remedies. Now, that you have become self-sufficient, hence it’s the right time to use your acquired knowledge for solving problems as per the provision available in Siddha Spirituality of Swami Hardas Life System.
However, keep learning and practicing the free Siddha remedies, which would help guide how to solve various problems regarding health, peace, and progress, without money and medicines.
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Frequently asked questions
Before posting your query, kindly go through them:
| What is myasthenia gravis?
Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. With current therapies, however, most cases of myasthenia gravis are not as “grave” as the name implies. In fact, most individuals with myasthenia gravis have a normal life expectancy. |
| What are the main risk factors of myasthenia gravis?
A 2018 Swedish study found that those with the late-onset disease had a more disadvantageous pattern of lifestyle-related risk factors and a higher rate of: Smoking, Obesity, Physical inactivity, and Insufficient diet (including a lower rate of fish consumption). |
| Which are the preventive measures for myasthenia gravis?
Many lifestyle changes may help prevent flare-ups and lower the chances of worsening symptoms, these lifestyle changes include: Getting plenty of sleep, Taking rest periods when needed, Avoiding strenuous or exhausting activities, Staying out of the extreme heat and cold, Coping with emotional stressors, Avoiding infections when possible, and Working with your healthcare provider to avoid drugs that worsen MG. |
Reference: https://en.wikipedia.org/wiki/Myasthenia_gravis
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