Down syndrome (DS or DNS), also known as trisomy 21, is a genetic disorder caused by the presence of all or part of the third copy of chromosome 21. It is typically associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. The average IQ of a young adult with Down syndrome is 50, equivalent to the mental ability of an 8- or 9-year-old child, but this can vary widely. In 2015, Down syndrome was present in 5.4 million individuals globally and resulted in 27,000 deaths, down from 43,000 deaths in 1990. The figures are shocking but people in need may learn and apply Free Siddha energy remedies of Siddha Spirituality of Swami Hardas Life System, which needs no money and medicines. Hence, let us know what is a down syndrome, symptoms, causes, diagnosis, treatments, stem cell therapy, and Free Siddha energy remedies.
Down syndrome definition
A congenital disorder arising from a chromosome defect, causing intellectual impairment and physical abnormalities including short stature and a broad facial profile. It arises from a defect involving chromosome 21, usually an extra copy (trisomy-21).
Down syndrome facts
There is no cure for Down syndrome.
Education and proper care have been shown to improve quality of life. Some children with Down syndrome are educated in typical school classes, while others require more specialized education.
Down syndrome is one of the most common chromosome abnormalities in humans. It occurs in about one per 1,000 babies born each year.
In 2015, Down syndrome was present in 5.4 million individuals globally and resulted in 27,000 deaths, down from 43,000 deaths in 1990.
Down syndrome life expectancy
Life expectancy is around 50 to 60 years in the developed world with proper health care.
Down syndrome symptoms
Those with Down syndrome nearly always have physical and intellectual disabilities. As adults, their mental abilities are typically similar to those of an 8 or 9-year-old. They also typically have a poor immune function and generally, reach developmental milestones at a later age. They have an increased risk of a number of other health problems, including a congenital heart defect, epilepsy, leukemia, thyroid diseases, and mental disorders.
| Characteristics | Percentage | Characteristics | Percentage |
|---|---|---|---|
| Mental impairment | 99% | Abnormal teeth | 60% |
| Stunted growth | 90% | Slanted eyes | 60% |
| Umbilical hernia | 90% | Shortened hands | 60% |
| Increased skin on the back of the neck | 80% | Short neck | 60% |
| Low muscle tone | 80% | Obstructive sleep apnea | 60% |
| The narrow roof of the mouth | 76% | Bent fifth fingertip | 57% |
| Flathead | 75% | Brushfield spots in the iris | 56% |
| Flexible ligaments | 75% | Single transverse palmar crease | 53% |
| Proportionally large tongue | 75% | Protruding tongue | 47% |
| Abnormal outer ears | 70% | Congenital heart disease | 40% |
| Flattened nose | 68% | Strabismus | ~35% |
| Separation of first and second toes | 68% | Undescended testicles | 20% |
Down syndrome Physical characteristics
People with Down syndrome may have some or all of the physical characteristics:
- A small chin
- Slanted eyes
- Poor muscle tone
- A flat nasal bridge
- A single crease of the palm
- A protruding tongue due to a small mouth and relatively large tongue
These airway changes lead to obstructive sleep apnea in around half of those with Down syndrome. Other common features include:
- A flat and wide face
- A short neck
- Excessive joint flexibility
- Extra space between the big toe and second toe
- Abnormal patterns on the fingertips and short fingers
Instability of the atlantoaxial joint occurs in about 20% and may lead to spinal cord injury in 1–2%. Hip dislocations may occur without trauma in up to a third of people with Down syndrome.
Growth in height is slower, resulting in adults who tend to have short stature—the average height for men is 154 cm (5 ft 1 in) and for women is 142 cm (4 ft 8 in).
Individuals with Down syndrome are at increased risk for obesity as they age. Growth charts have been developed specifically for children with Down syndrome.
Despite growth retardation, the difference in height between the sexes is the same as that found in healthy individuals. Even though puberty appears somewhat early, the charts show that DS individuals have a decreased pubertal growth rate. Our growth charts show that European boys with DS are taller than corresponding American boys, whereas European girls with DS, although being lighter, have a similar height to corresponding American girls.
Neurological
This syndrome causes about a third of cases of intellectual disability. Many developmental milestones are delayed with the ability to crawl typically occurring around 8 months rather than 5 months and the ability to walk independently typically occurring around 21 months rather than 14 months.
Most individuals with Down syndrome have mild (IQ: 50–69) or moderate (IQ: 35–50) intellectual disability with some cases having severe (IQ: 20–35) difficulties. Those with mosaic Down syndrome typically have IQ scores 10–30 points higher. As they age, people with Down syndrome typically perform worse than their same-age peers.
Commonly, individuals with Down syndrome have better language understanding than the ability to speak. Between 10 and 45% have either a stutter or rapid and irregular speech, making it difficult to understand them. Some after 30 years of age may lose their ability to speak.
They typically do fairly well with social skills. Behavior problems are not generally as great an issue as in other syndromes associated with intellectual disability. In children with Down syndrome, mental illness occurs in nearly 30% with autism occurring in 5–10%.
People with Down syndrome experience a wide range of emotions. While people with Down syndrome are generally happy, symptoms of depression and anxiety may develop in early adulthood.
Children and adults with Down syndrome are at increased risk of epileptic seizures, which occur in 5–10% of children and up to 50% of adults. This includes an increased risk of a specific type of seizure called infantile spasms. Many (15%) who live 40 years or longer develop Alzheimer disease. In those who reach 60 years of age, 50–70% have the disease.
Senses
Hearing and vision disorders occur in more than half of people with Down syndrome. Vision problems occur from 38 to 80%. Between 20 and 50% have strabismus, in which the two eyes do not move together. Cataracts (cloudiness of the lens of the eye) occur in 15% and may be present at birth.
Heart
The rate of congenital heart disease in newborns with Down syndrome is around 40%. Of those with heart disease, about 80% have an atrioventricular septal defect or ventricular septal defect with the former being more common.
Mitral valve problems become common as people age, even in those without heart problems at birth. Other problems that may occur include tetralogy of Fallot and patent ductus arteriosus. People with Down syndrome have a lower risk of hardening of the arteries.
Cancer
Although the overall risk of cancer in DS is not changed, the risk of testicular cancer and certain blood cancers, including acute lymphoblastic leukemia (ALL) and acute megakaryoblastic leukemia (AMKL) is increased while the risk of other nonblood cancers is decreased. People with DS are believed to have an increased risk of developing cancers derived from germ cells whether these cancers are blood or non-blood related.
Blood Cancers
Leukemia is 10 to 15 times more common in children with Down syndrome. In particular, acute lymphoblastic leukemia is 20 times more common and the megakaryoblastic form of acute myeloid leukemia (acute megakaryoblastic leukemia), is 500 times more common.
In Down syndrome, AMKL is typically preceded by transient myeloproliferative disease (TMD), a disorder of blood cell production in which non-cancerous megakaryoblasts with a mutation in the GATA1 gene rapidly divide during the later period of pregnancy.
The condition affects 3–10% of babies with Down. While it often spontaneously resolves within three months of birth, it can cause serious blood, liver, or other complications. In about 10% of cases, TMD progresses to AMKL during the three months to five years following its resolution.
Non-blood cancers
People with DS have a lower risk of all major solid cancers including those of lung, breast, cervix, with the lowest relative rates occurring in those aged 50 years or older. This low risk is thought due to an increase in the expression of tumor suppressor genes present on chromosome 21. One exception is testicular germ cell cancer which occurs at a higher rate in DS.
Endocrine
Problems of the thyroid gland occur in 20–50% of individuals with Down syndrome. Low thyroid is the most common form, occurring in almost half of all individuals. Thyroid problems can be due to a poorly or nonfunctioning thyroid at birth which occurs in 1% or can develop later due to an attack on the thyroid by the immune system resulting in Graves’ disease or autoimmune hypothyroidism. Type 1 diabetes mellitus is also more common.
Gastrointestinal
Constipation occurs in nearly half of people with Down syndrome and may result in changes in behavior. One potential cause is Hirschsprung’s disease, occurring in 2–15%, which is due to a lack of nerve cells controlling the colon.
Other frequent congenital problems include:
- Duodenal atresia
- Pyloric stenosis
- Meckel diverticulum
- Imperforate anus
Celiac disease affects about 7–20% and gastroesophageal reflux disease are also more common.
Teeth
Individuals with Down syndrome tend to be more susceptible to gingivitis as well as early, severe periodontal disease, necrotizing ulcerative gingivitis, and early tooth loss, especially in the lower front teeth.
While plaque and poor oral hygiene are contributing factors, the severity of these periodontal diseases cannot be explained solely by external factors.
Individuals with Down syndrome also tend to have more alkaline saliva resulting in greater resistance to tooth decay, despite decreased quantities of saliva, less effective oral hygiene habits, and higher plaque indexes.
Higher rates of tooth wear and bruxism are also common. Other common oral manifestations of Down syndrome include:
- Enlarged hypotonic tongue
- Crusted and hypotonic lips
- Mouth breathing
- Narrow palate with crowded teeth
- Class III malocclusion with an underdeveloped maxilla and posterior crossbite
- Delayed exfoliation of baby teeth and delayed eruption of adult teeth
- Shorter roots on teeth
- Missing and malformed (usually smaller) teeth
Less common manifestations include cleft lip and palate and enamel hypocalcification (20% prevalence).
Fertility
Males with Down syndrome usually do not father children, while females have lower rates of fertility relative to those who are unaffected. Fertility is estimated to be present in 30–50% of females. Menopause typically occurs at an earlier age.
The poor fertility in males is thought to be due to problems with sperm development; however, it may also be related to not being sexually active.
Down syndrome Causes
Down syndrome is caused by having three copies of the genes on chromosome 21, rather than the usual two. The parents of the affected individual are typically genetically normal.
The extra chromosome content can arise in several different ways. The most common cause (about 92–95% of cases) is a complete extra copy of chromosome 21, resulting in trisomy 21.
The other common mechanisms that can give rise to Down syndrome include:
- A Robertsonian translocation
- Isochromosome
- Ring chromosome
These contain additional material from chromosome 21 and occur in about 2.5% of cases. An isochromosome results when the two long arms of a chromosome separate together rather than the long and short arm separating together during egg or sperm development.
Trisomy 21
Trisomy 21 (also known by the karyotype 47, XX,+21 for females and 47, XY,+21 for males) is caused by a failure of the 21st chromosome to separate during egg or sperm development. As a result, a sperm or egg cell is produced with an extra copy of chromosome 21; this cell thus has 24 chromosomes.
When combined with a normal cell from the other parent, the baby has 47 chromosomes, with three copies of chromosome 21. About 88% of cases of trisomy 21 results from nonseparation of the chromosomes in the mother, 8% from nonseparation in the father, and 3% after the egg and sperm have merged.
Translocation
The extra chromosome 21 material may also occur due to a Robertsonian translocation in 2–4% of cases. In this situation, the long arm of chromosome 21 is attached to another chromosome, often chromosome 14.
In a male affected with Down syndrome, it results in a karyotype of 46XY,t(14q21q). This may be a new mutation or previously present in one of the parents. The parent with such a translocation is usually normal physically and mentally; however, during the production of egg or sperm cells, a higher chance of creating reproductive cells with extra chromosome 21 material exists.
This results in a 15% chance of having a child with Down syndrome when the mother is affected and a less than 5% probability if the father is affected. The probability of this type of Down syndrome is not related to the mother’s age.
Some children without Down syndrome may inherit the translocation and have a higher probability of having children of their own with Down syndrome. In this case, it is sometimes known as familial Down syndrome.
Down syndrome diagnosis
Before birth
When screening tests predict a high risk of Down syndrome, a more invasive diagnostic test is needed to confirm the diagnosis. If Down syndrome occurs in one in 500 pregnancies and the test used has a 5% false-positive rate, this means, of 26 women who test positive on screening, only one will have Down syndrome confirmed.
Down syndrome abortion
About 92% of pregnancies in Europe with a diagnosis of Down syndrome are terminated. As a result, there are almost no people with Down’s in Iceland and Denmark, where screening is commonplace.
In the United States, the termination rate after diagnosis is around 75% but varies from 61% to 93% depending on the population surveyed. Rates are lower among women who are younger and have decreased over time.
After birth
The diagnosis can often be suspected based on the child’s physical appearance at birth. An analysis of the child’s chromosomes is needed to confirm the diagnosis, and to determine if a translocation is present, as this may help determine the risk of the child’s parents having further children with Down syndrome. Parents generally wish to know the possible diagnosis once it is suspected and do not wish pity.
Down syndrome screening
The different screening techniques in use are able to pick up 90–95% of cases with a false-positive rate of 2–5%:
| Screen | Week of Pregnancy when performed | Detection Rate | False Positive | Description |
|---|---|---|---|---|
| Combined test | 10–13.5 Wks | 82–87% | 5% | Uses ultrasound to measure nuchal translucency in addition to blood tests for free or total beta-hCG and PAPP-A |
| Quad screen | 15–20 Wks | 81% | 5% | Measures the maternal serum alpha-fetoprotein, unconjugated estriol, hCG, and inhibin-A |
| Integrated test | 15–20 Wks | 94–96% | 5% | Is a combination of the quad screen, PAPP-A, and NT |
| Cell-free fetal DNA | From 10 Wks | 96–100% | 0.3% | A blood sample is taken from the mother by venipuncture and is sent for DNA analysis. |
Down syndrome Ultrasound
Ultrasound imaging can be used to screen for Down syndrome. Findings that indicate increased risk when seen at 14 to 24 weeks of gestation include a small or no nasal bone, large ventricles, nuchal fold thickness, and an abnormal right subclavian artery, among others.
The presence or absence of many markers is more accurate. Increased fetal nuchal translucency (NT) indicates an increased risk of Down syndrome picking up 75–80% of cases and being falsely positive in 6%.
Blood tests
Several blood markers can be measured to predict the risk of Down syndrome during the first or second trimester. Testing in both trimesters is sometimes recommended and test results are often combined with ultrasound results.
In the second trimester, often two or three tests are used in combination with two or three of:
- A-fetoprotein
- Unconjugated estriol
- Total hCG
- Free ?hCG detecting about 60–70% of cases
Testing of the mother’s blood for fetal DNA is being studied and appears promising in the first trimester. The International Society for Prenatal Diagnosis considers it a reasonable screening option for those women whose pregnancies are at high risk for trisomy 21.
Accuracy has been reported at 98.6% in the first trimester of pregnancy. Confirmatory testing by invasive techniques is still required to confirm the screening result.
Down syndrome Management
Efforts such as early childhood intervention, screening for common problems, medical treatment where indicated, a good family environment, and work-related training can improve the development of children with Down syndrome.
Education and proper care can improve quality of life. Raising a child with Down syndrome is more work for parents than raising an unaffected child. Typical childhood vaccinations are recommended.
Health screening
A number of health organizations have issued recommendations for screening those with Down syndrome for particular diseases. This is recommended to be done systematically.
Cognitive development
Hearing aids or other amplification devices can be useful for language learning in those with hearing loss. Speech therapy may be useful and is recommended to be started around nine months of age.
As those with Down syndrome typically have good hand-eye coordination, learning sign language may be possible. Augmentative and alternative communication methods, such as pointing, body language, objects, or pictures, are often used to help with communication.
Behavioral issues and mental illness are typically managed with counseling or medications.
Education programs before reaching school age may be useful. School-age children with Down syndrome may benefit from inclusive education, provided some adjustments are made to the curriculum. Evidence to support this, however, is not very strong.
In the United States, the Individuals with Disabilities Education Act of 1975 requires public schools generally to allow attendance by students with Down syndrome.
Individuals with Down syndrome may learn better, visually. Drawing may help with language, speech, and reading skills.
Children with Down syndrome still often have difficulty with sentence structure and grammar, as well as developing the ability to speak clearly.
Several types of early intervention can help with cognitive development. Efforts to develop motor skills include:
Physical therapy focuses specifically on motor development and teaching children to interact with their environment.
Speech and language therapy can help prepare for later language.
Lastly, occupational therapy can help with skills needed for later independence. To watch a video clip, please click.
Down syndrome & Stem Cell Therapy
Stem cell technology provides plenty of novel means for disease treatment. Down syndrome is one of the diseases that is known as untreatable.
So far, there is no effective treatment for Down syndrome except for physiotherapy and special education. However, physiotherapy and special education can only help children with Down syndrome to a certain level.
Neural stem cell transplantation therapy is used in treating patients with Down syndrome. 300 Down syndrome patients have been treated with neural stem cell transplantation therapy.
Patients’ age is from 8 months to 8 years. Most of the patients showed different levels of improvements in intellectual development, gait, speech, muscle strength and reaction velocity. Desirous persons can contact “Journal of Stem Cell Research & Therapy” at +441902928240 for further inquiries.
Down syndrome & Free Siddha Energy Remedies
1. Siddha preventive measures for down syndrome
Everybody must practice Siddha preventive measures, whether affected with down syndrome or not, but they are the primary steps for switching on to any other Siddha energy remedies, and hence they are important. It helps in one’s capability, effectiveness, productivity, decision making power, intellectuality and removing minor health problems.
Earthing, Field Cleaning, and Siddha Brain Exercise/Energizing are three types of preventive measures. Everybody’s tendency is to get attracted toward the word ‘free‘, however, don’t neglect even these Siddha preventive measures are free. Avail the benefits by practicing them regularly. For the ease of understanding Siddha preventive measures, please watch a video for a live demonstration.
2. Siddha Shaktidata Yog for down syndrome
3. Siddha Kalyan Sadhana for down syndrome
Recite this Sadhana with a Sankalp “My down syndrome problem be solved as early as possible and I should gain health”, which should be repeated in mind 3 – 3 times every after each stanza. Any person irrespective of caste, creed, religion, faith, sex, and age can recite this Sadhana for free, which should be repeated at least twice in a day. To know more about, please click on this link.
4. CCPE products for down syndrome
These products work on the concepts of ‘Conceptual Creative Positive Energy’ (CCPE) within the provisions of ‘CCPE Life System’ and the theory of Quantum Technology to a certain extent. However, the products get activated only whenever touched by a human and then they become capable of solving the problem and achieving health.
The use of CCPE products, being Energy Therapy, is one of the most effective free Siddha energy remedies for the persons, who could not undergo training of Siddha Spirituality of Swami Hardas Life System. However, please use these products for the down syndrome as mentioned below:
CCPE Extractor
The CCPE Extractor should be gently moved over the Agya Chakra in a circular motion at least for 30 to 60 seconds, thereafter, follow the same process on the head, throat, heart, naval for another 30 to 60 seconds, which will convert negativity into positivity. This is how the process of using extractor finishes within almost 3 – 6 minutes. It is so simple.
CCPE Booster
Keep one Booster over the Agya Chakra and another over the head, throat, heart, naval for 3 to 5 minutes. You may need to have 5 Boosters and the process would finish within almost 3 – 5 minutes, which establishes positivity. This is how the process of using Booster finishes within almost 3 – 5 minutes with 5 Boosters. It is so simple.
Wrapping boosters in a thin cloth and tying around the head and naval overnight to achieve faster results is permissible but after the use of CCPE Extractor as explained above.
5. UAM for down syndrome
UAM (Understanding, Awakening & Movement): It is an energy-based process which can be applied by the persons who have undergone training for touch therapy. One should have attended a minimum age of 18 years to avail of this golden opportunity. A desirous person can undergo training-process irrespective of caste, creed, religion, faith, and sex. Trained persons can follow the tips explained below for how to apply these free Siddha energy remedies for down syndrome:
- Touch therapy – UAM/leveling
- Distant therapy – Siddha Shaktidata Yog, Sight healing
- Sankalp therapy – Siddha Kalyan Sadhana, Vishwa Kalyan Sadhana
- Energy therapy – Use of CCPE products e.g. CCPE Extractor, Booster, and Booster powder
There are various reasons behind health, peace, and progress related problems, but effective free Siddha energy remedies would help solve all of them.
You may also like to read about eyes, nose, obesity, arthritis, arthritis in the knee, Knee pain, spondylosis, lower back pain, stem cell, speech therapy, physical therapy, occupational therapy, hydrotherapy, and neurotransmitters.
Conclusion
In view of the above, I am confident that you have learned the basics of what is Down syndrome, definition, symptoms, causes, and various therapies. As a bonus, you also learned free Siddha energy remedies. Now its right time to use acquired knowledge for solving problems related to Down syndrome for free, without money and medicines. The sufferers know, how risky and insulting this problem is in society! Hence, learn Siddha energy remedies and apply them instantly to get or give instant relief to the needy.
DISCLAIMER
The opinions expressed in this article are the personal opinions of the concerned site owners. Siddha Spirituality For Health is not responsible for the accuracy, completeness, suitability, or validity of any information on this article. However, it is advisable to consult a specialist in the concerned field before availing the benefits. Hence we do not assume any responsibility or liability for the same.
Reference: https://en.wikipedia.org/wiki/Down_syndrome
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